杨朝勇 教授，博士生导师

电话：0592-2187601

E-mail: cyyang@xmu.edu.cn

实验室网址：http://www.yang-lab.com/

主要经历：

1994-1998 厦门大学 本科

1998-2001 厦门大学 硕士

2001-2006 美国佛罗里达大学 博士

2006-2007 美国加州大学伯克利分校 博士后

2008-至今 厦门大学化学化工学院 教授

研究领域：

体外诊断新方法, 创新仪器，微流控技术在生物医学中的应用, 单细胞分析, 纳米生物医学工程, 功能化DNA纳米组装。

主要科研项目：

1. 国家重大科研仪器研制项目，自动化单细胞多组学分析系统，2020.01-2024.12，在研。

2. 科技部国家重点研发计划合成生物学专项课题，高通量DNA生物合成微流控模块研发，2020.01-2024.12，在研。

3. 国家自然科学基金委重点项目，循环肿瘤细胞高效分型捕获与高通量单细胞转录组测序分析，2018.01-2022.12，在研。

4. 国家自然科学基金委杰出青年基金，生物分析化学，2014.01-2017.12，结题（优秀）。

5. 国家自然科学基金委重大研究计划集成项，基于化学小分子探针的信号转导过程研究，2014.01-2015.12，已结题。

6. 国家基金委面上项目，核酸适体功能化微流控芯片用于循环肿瘤细胞的捕获富集检测, 2013.01-2016.12，已结题。

7. 科技部国家重大科学仪器设备开发专项，等离激元增强拉曼光谱仪器研发与应用，2011.10-2015.09，已结题。

8. 科技部973课题，核酸适体分子识别体系的设计与生物标志物的甄定， 2010.01-2014.12，已结题。

代表性成果：

1. Lin, L#; Zhang, Y#; Qian, W#; Liu, Y; Zhang, Y; Lin, F; Liu, C; Lu, G; Sun, D; Guo, X; Song, Y; Song, J*; Yang, C*; Li J*, LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis, PNAS, 2022, 119, e2119767119.

2. Sun, M#; Liu, S#; Song, T; Chen, F; Zhang, J; Huang, J; Wan, S; Lu, Y; Chen, H*; Tan, W*; Song, Y*; Yang, C*; Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape, J.Am.Chem.Soc., 2021, 143, 21541-21548.

3. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Zhu, L; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARSCoV2 Virus Infection, Angew. Chem. Int. Ed. 2021, 60, 2-9. (hot paper)

4. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed. 2021, 60, 7582-7586.

5. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev. 2021, 121, 12035–12105.

6. Huang, M#; Li,T#; Xu, Y; Wei, X; Song, J; Lin,B; Zhu, Z; Song, Y*; and Yang, C*; Activation of Aptamers with Gain-of-Function by Small-Molecule Clipping of Intramolecular Motifs, Angew. Chem. Int. Ed. 2021, 60, 6021-6028.

7. Ruan, Q; Ruan, W; Lin, X; Wang, Y; Zou, F; Zhou, L; Zhu, Z; Yang, C*; Digital-WGS: Automated, Highly Efficient Whole-genome Sequencing of Single Cells by Digital Microfluidics, Sci. Adv. 2020, 6: eabd6454.

8. Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*; Revealing the in vivo Growth and Division Patterns of Mouse Gut Bacteria, Sci Adv. 2020, 6: eabb2531.

9. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew Chem. Int. Ed. 2020, 132, 2-9.

10. Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed, 2020, 59, 14115-14119.

11. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W.*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling, Angew. Chem. Int. Ed. 2020, 59, 11923-11926.

12. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C *; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers, Nat. Commun. 2020, 11, 2118.

13. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc 2020, 142, 4800-4806.

14. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction, Angew. Chem. Int. Ed. 2020, 59, 4800-4805.

15. Wang, W; Yang, Q; Du, Y; Zhou, X; Du, X; Wu, Q; Lin, L; Song, Y; Li, F; Yang, C*; Tan, W*; Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota, Angew. Chem. Int. Ed. 2020, 59, 2628-2633.

16. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*; Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes, Nature Commun. 2019, 10, 1317.

17. Li, Y; Ma, Y; Jiao, X; Li, T; Lv, Z；Yang, C*; Zhang, X*; Wen, Y*; Control of Capillary Behavior Through Target-responsive Hydrogel Permeability Alteration for Sensitive Visual Quantitative Detection, Nature Commun. 2019, 10, 1036.

18. Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed. 2019, 58, 2236-2240.

19. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*; A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami, J. Am. Chem. Soc. 2018, 28, 8990-8996.

20. Gashaw, M; Abate, M; Song, Y; Zhu, Z; Yan, F; Xu, Y; Wang, X; Li, Q; Yang, C*. Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip, Angew. Chem. Int. Ed. 2017, 56, 10681-10685.